Search on: GTP CYCLOHYDROLASE 
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Descriptor English:   GTP Cyclohydrolase 
Descriptor Spanish:   GTP Ciclohidrolasa 
Descriptor Portuguese:   GTP Cicloidrolase 
Synonyms English:   7,8 Dihydroneopterintriphosphate Synthetase
7,8-Dihydroneopterintriphosphate Synthetase
8-Formylhydrolase, GTP
Cyclohydrolase I, GTP
Cyclohydrolase II, GTP
Cyclohydrolase, GTP
Dihydrolase, GTP
GTP 8 Formylhydrolase
GTP 8-Formylhydrolase
GTP Cyclohydrolase I
GTP Cyclohydrolase II
GTP Dihydrolase
GTP Ring Opening Enzyme
GTP Ring-Opening Enzyme
Ring-Opening Enzyme, GTP
Synthetase, 7,8-Dihydroneopterintriphosphate  
Tree Number:   D08.811.277.151.300
Definition English:   (GTP cyclohydrolase I) or GTP 7,8-8,9-dihydrolase (pyrophosphate-forming) (GTP cyclohydrolase II). An enzyme group that hydrolyzes the imidazole ring of GTP, releasing carbon-8 as formate. Two C-N bonds are hydrolyzed and the pentase unit is isomerized. This is the first step in the synthesis of folic acid from GTP. EC 3.5.4.16 (GTP cyclohydrolase I) and EC 3.5.4.25 (GTP cyclohydrolase II). 
History Note English:   91(75); was see under AMINOHYDROLASES 1975-90 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   6285 
Unique Identifier:   D006136 

Occurrence in VHL: 		 

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